Thursday, 14 January 2016



Lassa hemorrhagic fever (LHF) is an acute viral hemorrhagic fever caused by the Lassa virus and first described in 1969 in the town of Lassa, in Borno State, Nigeria. Lassa fever is a member of the Arenaviridae virus family. Similar to ebola, clinical cases of the disease had been known for over a decade, but had not been connected with a viral pathogen. Lassa frequently infects peoplein West Africa. It results in 300,000 to 500,000 cases annually and causes about 5,000 deaths each year. Outbreaks of the disease have been observed in Nigeria, Liberia, Sierra Leone, Guinea, and the Central African Republic. The primary animal host of the Lassa virus is the Natal multimammate mouse (Mastomys natalensis), an animal found in most of sub-Saharan Africa. The virus is probably transmitted by contact with the feces or urine of animals accessing grain stores in residences. Given its high rate of incidence, Lassa fever is a major problem in affected countries.
Signs and symptoms
Causes

Diagnosis
Prevention
Treatment
Prognosis
Epidemiology

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  • Diagnosis A range of laboratory investigations are performed to diagnose the disease and assess its course and complications. An ELISA test for antigen and IgM antibodies give 88% sensitivity and 90% specificity for the presence of th… Read More
  • Prevention Control of the Mastomys rodent population is impractical, so measures are limited to keeping rodents out of homes and food supplies, as well as maintaining effective personal hygiene. Gloves, masks, laboratory coats, and gog… Read More
  • Prognosis About 15-20% of hospitalized Lassa fever patients will die from the illness. The overall mortality rate is estimated to be 1%, but during epidemics, mortality can climb as high as 50%. The mortality rate is greater than 80% … Read More
  • Symptoms of Lassa Fever In 80% of cases, the disease is asymptomatic, but in the remaining 20%, it takes a complicated course. The virus is estimated to be responsible for about 5,000 deaths annually. The fever accounts for up to one-third of death… Read More
  • Epidemiology The dissemination of the infection can be assessed by prevalence of antibodies to the virus in populations of: *.Sierra Leone - 8–52% *.Guinea - 4–55% *.Nigeria - about 21% Lassa fever is a viral hemorrhagic fever in West Af… Read More

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