Thursday, 14 January 2016

In 80% of cases, the disease is asymptomatic, but in the remaining 20%, it takes a complicated course. The virus is estimated to be responsible for about 5,000 deaths annually. The fever accounts for up to one-third of deaths in hospitals within the affected regions and 10 to 16% of total cases.
After an incubation period of six to 21 days, an acute illness with multiorgan involvement develops. Nonspecific symptoms include fever, facial swelling, and muscle fatigue, as well as conjunctivitis and mucosal bleeding. The other symptoms arising from the affected organs are:
*. Gastrointestinal tract
*. Nausea
*. Vomiting (bloody)
*. Diarrhea(bloody)
*. Stomach ache
*. Constipation
*. Dysphagia(difficulty swallowing)
*. Hepatitis
*. Cardiovascular system
*. Pericarditis
*. Hypertension
*. Hypotension
*. Tachycardia (abnormally high heart rate)
*. Respiratory tract
*. Cough
*.Chest pain
*. Dyspnoea
*. Pharyngitis
*. Pleuritis
*. Nervous system
*. Encephalitis
*. Meningitis
*.Unilateral or bilateral hearing deficit
Lassa fever infections are difficult to distinguish from other viral hemorrhagic fevers such as Ebola and Marburg, and from more common febrileillnesses such as malaria.
The virus is excreted in urine for 3-9 weeks and in semen for three months.

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  • Epidemiology The dissemination of the infection can be assessed by prevalence of antibodies to the virus in populations of: *.Sierra Leone - 8–52% *.Guinea - 4–55% *.Nigeria - about 21% Lassa fever is a viral hemorrhagic fever in West Af… Read More
  • Causes Lassa virus is zoonotic (transmitted from animals), in that it spreads to humans from rodents, specifically multimammate mice (Mastomys natalensis). This is probably the most common mouse in equatorial Africa, ubiquitous in … Read More
  • Treatment All persons suspected of Lassa fever infection should be admitted to isolation facilities and their body fluids and excreta properly disposed of. Early and aggressive treatment using ribavirinwas pioneered by Joe McCormi… Read More
  • Prognosis About 15-20% of hospitalized Lassa fever patients will die from the illness. The overall mortality rate is estimated to be 1%, but during epidemics, mortality can climb as high as 50%. The mortality rate is greater than 80% … Read More
  • Lassa Fever Lassa hemorrhagic fever (LHF) is an acute viral hemorrhagic fever caused by the Lassa virus and first described in 1969 in the town of Lassa, in Borno State, Nigeria. Lassa fever is a member of the Arenaviridae virus fam… Read More

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